Health & Living

COVID-19 vaccine and organ transplant recipients: strict adherence to security protocols should even after second vaccine

Little has been mentioned concerning the effectiveness of the COVID-19 vaccine in organ transplant recipients. This group of individuals are immunocompromised and really weak. Now, a brand new examine from Johns Hopkins College College of Drugs signifies that though two doses of a vaccine in opposition to the virus that causes COVID 19 does provide some safety for individuals who have obtained stable organ transplants, it’s nonetheless not sufficient to permit them to do with out masks. , bodily distance and different safety measures. the Journal of the American Medical Affiliation (JAMA) printed this examine. It is a follow-up examine to an earlier examine printed in March in JAMA, through which researchers reported that solely 17% of taking part transplant recipients produced sufficient antibodies after a single dose of a routine. two-dose COVID-19 vaccine. Learn additionally – Miracle cure for COVID-19: Scientists say anti-parasitic drug ivermectin could be key to ending pandemic

Antibodies detectable after vaccination in transplant sufferers low

Researchers say that though there was a rise within the variety of individuals with antibody – 54% total – after the second injection, the variety of transplant recipients within the second examine whose antibody ranges reached ranges excessive sufficient to forestall SARS-CoV-2 an infection was nonetheless properly beneath of what’s usually seen in individuals with wholesome immune methods. This appears to recommend that organ transplant recipients will not be as protected by the COVID-19 vaccine as the overall inhabitants. Learn additionally – Maharashtra to set up Covid pediatric task force: takes experts’ warning seriously about third wave of COVID-19

Security precautions must be taken for immunocompromised sufferers

Based mostly on these outcomes, the researchers advocate that transplant recipients and different immunocompromised sufferers proceed to apply strictly. COVID-19 Safety Precautionseven after vaccination. Individuals who have stable organ transplants (comparable to hearts, lungs, and kidneys) typically have to take medication to suppress their immune system and forestall rejection. Such patterns can intervene with the flexibility of a transplant recipient to make antibodies in opposition to overseas substances, together with protecting antibodies produced in response to vaccines. Learn additionally – Coronavirus 2nd Wave: India’s approval of anti-COVID nasal spray may be a game-changer

Research based mostly on response to Moderna and Pfizer jabs

The brand new examine evaluated this immunogenic response after the second dose of certainly one of two messenger RNA (mRNA) vaccines – manufactured by Moderna and Pfizer-BioNTech – for 658 transplant recipients, none of whom had a earlier prognosis of COVID-19[feminine. Les participants ont terminé leur régime à deux doses entre le 16 décembre 2020 et le 13 mars 2021. Dans l’étude la plus récente, les chercheurs ont constaté que seuls 98 des 658 participants à l’étude – 15% – avaient des anticorps détectables contre le SRAS-CoV. -2 à 21 jours après la première dose de vaccin. Cela était comparable aux 17% rapportés dans l’étude de mars portant sur la réponse immunitaire après une seule dose de vaccin. À 29 jours après la deuxième dose, le nombre de participants avec des anticorps détectables est passé à 357 sur 658 – 54 pour cent. Après l’administration des deux doses de vaccin, 301 participants sur 658 – 46 pour cent – n’avaient aucun anticorps détectable tandis que 259 – 39 pour cent – ne produisaient d’anticorps qu’après le deuxième vaccin.

Les patients plus jeunes s’en sortent mieux que les receveurs plus âgés après les injections

Les chercheurs ont également constaté que parmi les participants, les plus susceptibles de développer une réponse anticorps étaient plus jeunes, ne suivaient pas de régime immunosuppresseur comprenant des médicaments anti-métabolites et recevaient le Vaccin Moderna. Celles-ci étaient similaires aux associations observées dans l’étude à dose unique de mars. Par conséquent, les chercheurs disent que les receveurs de greffe ne devraient pas supposer que deux doses de vaccin garantissent une immunité suffisante contre le virus COVID-19, pas plus qu’après une seule dose.

(Avec les contributions des agences)

Publié: 8 mai 2021 22h01

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